Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing
Reexamination Certificate
2009-08-13
2011-12-13
Zucker, Paul A (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heavy metal containing
C556S107000
Reexamination Certificate
active
08076499
ABSTRACT:
A method for preparing a precursor of radioactive 3-iodobenzylguanidine- N,N′-bis(tert-butyloxycarbonyl)-3-(tri-n-butyltin)benzylguanidine) (MSnBG) is revealed. The method includes following steps. Firstly, obtain 3-iodobenzylguanidine bicarbonate by an addition reaction between 3-iodobenzylamine hydrochloride and cyanamide. Use di-tert-butyl dicarbonate as a protecting agent for NH group and convert 3-iodobenzylguanidine bicarbonate into N,N′-bis(tert-butyloxycarbonyl)-N-(3-iodobenzyl) guanidine. At last, under catalysis of bis(triphenylphosphine) palladium dichloride, obtain a final product MSnBG by a substitution reaction between N,N′-bis(tert-butyloxycarbonyl)-N-(3-iodobenzyl) guanidine and bis(tri-n-butyltin). MSnBG is used in no-carrier-added synthesis of [*l]MIBG.
REFERENCES:
Vaidynathan et al, Journal of Labeled compounds and Radiopharmaceuticals, A Tin Precursor for the Synthesis of No-carrier-added [*I]MIBG and [211At]MABG, 2007, 50, pp. 177-182.
Hsu Cheng-Fang
Lin Cheng-Hsien
Lin Tsyh-Lang
Liu Show-Wen
Atomic Energy Council-Institute of Nuclear Energy Research
Chow Ming
Sinorica LLC
Zucker Paul A
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