Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2004-02-24
2009-02-10
Aulakh, Charanjit S (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S042000
Reexamination Certificate
active
07488825
ABSTRACT:
A method for preparing a novel crystalline polymorphic irinotecan hydrochloride which is excellent in the solubility in water and reduced in the content of impurities is provided. A method for preparing c-type crystals of irinotecan hydrochloride having diffraction peaks (2θ) at 9.15°, 10.00°, 11.80°, 12.20°, 13.00° and 13.40° in the powder X-ray diffractometry characterized by mixing irinotecan with one or more solvents selected from the group consisting of acetone, acetonitrile and tetrahydrofuran, adding hydrochloric acid, and collecting the formed crystals.
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Pages 12, 14, 18 and 19 of 60/360,684.
Seigo Sawada: Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives: Carbamate-Linked, Water-Soluble Derivatives of 7-Ethyl-10-hydroxycamptothecin1), Chemical & Pharmaceutical Bulletin, vol. 39, No. 6, pp. 1446-1454, 1991.
Abe Atsuhiro
Sawada Seigo
Shimizu Hideaki
Yaegashi Takashi
Aulakh Charanjit S
Kabushiki Kaisha Yakul't Honsha
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
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