Method for preparing polyfunctionalized peptides and/or...

Details Method for preparing polyfunctionalized peptides and/or... Method for preparing polyfunctionalized peptides and/or...

2004-09-03

2009-12-22

Tsang, Cecilia (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Peptides containing saccharide radicals, e.g., bleomycins, etc.

C514S002600, C514S008100, C514S023000, C514S025000

Reexamination Certificate

active

07635750

ABSTRACT:
The present invention provides a method for preparing polyfunctionalized peptides and/or proteins at non-adjacent designated sites via native chemical ligation. In certain embodiments, the inventive method is a method for preparing a polyfunctionalized peptide comprising a peptidic backbone made up of four or more amino acids, wherein two or more non-adjacent amino acids are independently subsituted with a moiety having the structure: wherein A and L1are as defined herein. In certain other embodiments, the inventive method allows the preparation of polyfunctionalized peptides having the general structure: wherein A, RP0, RP1, PX1, RX2, L1, to, s, t and q are as defined herein.

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