Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1989-11-28
1991-02-26
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
424 88, 424 92, 435193, 435194, 530405, 530406, 530410, 530415, 530416, 530825, A61K 3910, C12N 912, C07K 308, C07K 1504
Patent
active
049962990
ABSTRACT:
Disclosed is a method for preparing pertussis toxin toxoid by a treatment pertussis toxin with formaldehyde, which comprises carrying out said treatment in the presence of lysine or glycine in combination with N-acetyltriptophan. The resultant toxoid does not exhibit toxicity reversion, thereby making the toxoid highly suitable for use in pertussis vaccines.
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patent: 4762710 (1988-08-01), Sekura
patent: 4784589 (1988-11-01), Robinson et al.
patent: 4788058 (1988-11-01), Parton et al.
patent: 4845036 (1989-07-01), Burns et al.
patent: 4849358 (1989-07-01), Chazono et al.
patent: 4885359 (1989-12-01), Ginnaga et al.
Journal of Bacteriology in Japan, 42, 288, (1987), Sato et al.
Aihara Katsutoshi
Ginnaga Akihiro
Morokuma Kazunori
Sakoh Mitsuo
Juridical Foundation The Chemo-Sero-Therapeutic Research Institu
Schain Howard E.
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