Method for preparing optically active 1-aminoindan derivatives

Details Method for preparing optically active 1-aminoindan derivatives Method for preparing optically active 1-aminoindan derivatives

1996-09-13

1997-06-17

Kumar, Shailendra

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564302, 564303, 564305, 564308, C07C20988, C07B 5700

Patent

active

056399138

ABSTRACT:
Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of mandelic acid. Parkinson's disease, dementia, epilepsy, convulsions, or seizures are treated by administering a compound of the formula: ##STR1##

REFERENCES:
patent: 2573645 (1951-10-01), Kerwin et al.
patent: 3123642 (1964-03-01), Temple et al.
patent: 3637740 (1972-01-01), Sarges
patent: 3886168 (1975-05-01), Himmele et al.
patent: 4029731 (1977-06-01), Sarges
patent: 4096173 (1978-06-01), Molloy
patent: 4792628 (1988-12-01), Oshiro et al.
patent: 4833273 (1989-05-01), Goel
patent: 5242919 (1993-09-01), Oshiro et al.
patent: 5387612 (1995-02-01), Youdim et al.
Martin et al., Journal of Medicinal Chemistry (Apr. 1974) 17(4): 409-413.
Martin et al., Journal of Medicinal Chemistry (Feb. 1973) 16(2):147-150.
Oshiro et al., Journal of Medicinal Chemistry (Jul. 1991) 34(7): 2004-2013.
Oshiro et al., Journal of Medicinal Chemistry (Jul. 1991) 34(7): 2014-2023.
Horn et al., The Journal of Pharmacology and Experimental Therapeutics (Mar. 1972) 180(3): 523-530.
Tekes et., Polish Journal Pharmacol. Pharm. (Jun. 1988) 40: 653-658.
The Parkinson Study Group, The New England Journal of Medicine (Jan. 1993) 328(3): 176-183.

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