Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1994-11-09
1997-02-04
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
540588, C07D22324, C07D40306
Patent
active
055999298
ABSTRACT:
An improved method for preparing opipramol (I) is disclosed, wherein iminostilbene (II) is reacted with 1-bromo-3-chloropropane in the presence of a weak base selected from a hydrogen phosphate salt and an acetate salt and in the presence of a phase transfer agent to produce N-(3-halopropyl)iminostilbene (III), which is mixture of N-(3-chloropropyl)iminostilbene and N-(3-bromopropyl)iminostilbene, and then N-(3-halopropyl)iminostilbene is reacted with N-(2-hydroxyethyl)piperazine to form opipramol, as shown in the following equations, where X is chlorine or bromine. ##STR1##
REFERENCES:
patent: 2965639 (1960-12-01), Schindler
patent: 3317515 (1967-05-01), Paquette
patent: 3668210 (1972-06-01), Nakanishi et al.
patent: 3679662 (1972-07-01), Morita et al.
S. J. Schmolka et al., N-Dimethylaminopropylation in a Solid-Liquid Two Phase System: Synthesis of Chlorpromazine, its Analogs, and Related Compounds, Synthesis, No. 1, Stuttgart, Germany, Jan. 1984, pp. 29-31.
Leo A. Paquette, Hydroxylamine Chemistry. V. O-(2-Hydroxyethyl) acetone Oxime p-Toluenesulfonate, a Useful Intermediate for the Preparation of Hydroxylamine Derivatives, 1964, vol. 29, pp. 3545-3548 month of publication not provided.
E. D. Bergmann et al., Some Derivatives of 5H-Dibenz[b.f]Azepine, Tetrahedron, 1968, vol. 24, pp. 1289-1292. month of publication not provided.
L. J. Kricka et al., Reactions of Condensed N-Heteroaromatic Molecules. J. Chem. Soc., 1972, pp. 2292-2293 month of publication not provided.
Gozlan, I. et al. J. Heterocycl. Chem. 19, 1569-1571 (1982).
Hannig, E. Pharmazie34, 670-671 (1979). CA Abstract No. 93:26248.
Ashkar Mishel
Gutman Daniella
Gollin Michael A.
Shah Mukund J.
Taro Pharmaceutical Industries Ltd
Wong King Lit
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