Method for preparing novel transcription factors and use

Details Method for preparing novel transcription factors and use Method for preparing novel transcription factors and use

2005-09-07

2008-10-07

Keys, Rosalynd (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ether doai

C568S592000

Reexamination Certificate

active

07432306

ABSTRACT:
The present invention has an object to develop novel compounds which are effective for the therapy of syndrome X, cancer, myxedema, vascular chronic inflammation and the like, and furthermore prevent/treat the restenosis caused in an artery expansion by a balloon or a stent and have the activity facilitating regenerative medicine by inhibiting rejection of own cells or tissues to be transplanted and the method for preparing the same. Novel acetal derivatives obtained by acylating the hydroxyl group at the 2-position of the orcylaldehyde which ascochlorin and its analogs have and thereafter bonding an alcohol to the aldehyde group in the presence of a basic catalyst are found to achieve the object.

REFERENCES:
patent: 1 616 856 (2006-01-01), None
Machine translation of JP 2005225851 A, published Aug. 25, 2005.
Database WPI, Section Ch, Week 200560, Derwent Publications Ltd., London, GB; AN 2005-586473, XP002340064 -& JP 2005 225851 A (Kitahara T) Aug. 25, 2005; p. 13, tables; p. 17, tables; p. 18, reaction scheme.
K. Mori et al.,Tetrahedron Letters, vol. 40, No. 14, 1984, pp. 2711-2720.
K. Mori et al.,Tetrahedron Letters, vol. 24, No. 14, 1983, pp. 1547-1548.

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