Method for preparing N.sup.6,8-disubstituted 3',5'-cyclic adenos

Details Method for preparing N.sup.6,8-disubstituted 3',5'-cyclic adenos Method for preparing N.sup.6,8-disubstituted 3',5'-cyclic adenos

1984-09-19

1986-01-28

Love, Ethel G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1512, C07H 1700

Patent

active

045672547

ABSTRACT:
A method for preparing an N.sup.6,8-disubstituted 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula ##STR1## wherein X denotes a halogen atom or ##STR2## N.sub.3, OH or OR, R being an alkyl or aralkyl group; A.sup..sym. denotes a hydrogen ion, alkali metal ion, ammonium ion or organic ammonium ion; and R.sub.1 denotes an alkyl or aromatic group, which method comprises reacting an 8-substituted 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula (II) ##STR3## wherein X and A.sup.61 are as defined above, with an aldehyde represented by the general formula

REFERENCES:
patent: 3856776 (1974-12-01), Cehovic et al.
patent: 4058659 (1977-11-01), Robins et al.
patent: 4458067 (1984-07-01), Yamaji et al.
Jon P. Miller et al, "Synthesis and Enzymatic and Inotropic Activity of Some New 8-Substituted and 6,8-Disubstituted Derivatives of Adenosine Cyclic 3',5'-Monophosphate," J. Med. Chem., 1980, 23, 242-251.
Boswell et al, Syntheses of 6,8-Disubstituted-9-.beta.-D-Ribofuranosylpurine 3',5'-Cyclic Phosphates, J. Heterocyclic Chem., 12, 1 (1975).
Morrison et al., Organic Chemistry, pp. 740-741 (3d Ed., 1973).
Uesugi et al, Journ. Amer. Chem. Soc., 94:15 (1972) pp. 5480-5486.

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