Method for preparing N-monosubstituted and N,N'-disubstituted un

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

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514218, C07D24308, A61K 3155

Patent

active

055323570

ABSTRACT:
The present invention relates generally to methods for the preparation of unsymmetrically substituted cyclic ureas of the formulae ##STR1## which are useful as HIV protease inhibitors. The methods provided go through an isourea intermediate.

REFERENCES:
M. A. Eissenstat and J. D. Weaver, J. Org. Chem. (1993), 58, 3387-3390 A Retro-Diels-Alder Approach to Oxazoles and Imidazoles.
H. Kohn et al, J. Org. Chem. (1977), 42(6), 941-948 Syntheses and Spectral Properties of Substituted Imidazolidinones and Imidazolines.

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