Method for preparing N-methyl 2-(3-pyridyl) (1R,2R)-2-tetrahydro

Details Method for preparing N-methyl 2-(3-pyridyl) (1R,2R)-2-tetrahydro Method for preparing N-methyl 2-(3-pyridyl) (1R,2R)-2-tetrahydro

1995-08-15

1997-11-18

Fan, Jane

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40104

Patent

active

056889569

ABSTRACT:
The present invention relates to a process for the preparation of (1R,2R)-N-methyl -2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxide of formula: ##STR1## which is particularly useful as an antihypertensive and as a cardioprotective agent.

REFERENCES:
patent: 5053415 (1991-10-01), Brewster et al.
patent: 5120852 (1992-06-01), Aloup et al.
Univ. of Notre Dame Press, 1972 (pp. 24-28, 32), Wilen, Tables of Resolving Agents and Optical Resolutions, English Original.
J. Med. Chem., vol. 35, No. 20 (1992) pp. 3613-3624, Brown, Chapman, Cook, Hart, McLay, Jordan et al., Synthesis and biological Activity of trans-(+/-)-N-Methyl-2-(3pyri, English Original.

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