Method for preparing N-acetylneuraminic acid

Details Method for preparing N-acetylneuraminic acid Method for preparing N-acetylneuraminic acid

1995-09-14

1997-09-09

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 84, 435232, 536 187, 536 552, 536125, C12P 1902, C12P 1906, C07H 302, C12N 908

Patent

active

056655746

ABSTRACT:
A method for preparing N-acetylneuraminic acid characterized in reacting N-acetylglucosamine with pyruvic acid in an alkaline condition by the action of N-acetylneuraminic acid lyase.

REFERENCES:
patent: 5071750 (1991-12-01), Kragl et al.
patent: 5162513 (1992-11-01), Wong
Ethan S. Simon et al., J. Am. Chem. Soc. 1988, 110, 7159-7163; "Synthesis of CMP-NeuAc from N-Acetylglucosamine: Generation of CTP from CMP using Adenylate Kinase.sup.1,2 ".
Mahn-Joo Kim et al., J. Am. Chem. Soc. 1988, 110, 6481-6486; "Enzymes in Carbohydrate Synthesis: N-Acetylneuraminic Acid Aldolase Catalyzed Reactions and Preparation of N-Acetyl-2-deoxy-D-neuraminic Acid Derivatives".
Udo Kragl et al., Angen. Chem. Int. Engl., 30 (1991) No. 7; "Enzymatic Two-Step Synthesis of N-Acetylneuraminic Acid in the Enzyme Membrane Reactor".
Tomoaki Tanase et al., J. Chem. Soc., Chem. Commun., 1986, 1001-1003; "Novel C-2 Epimerization of Aldoses and Stereoselective Uptake of One of the Epimeric Aldoses by Nickel(II) Complexes".
Norman E. Good et al., Biochemistry, vol. 5, No. 2, 467-477, 1966; "Hydrogen Ion Buffers for Biological Research".
Toshiaki Imamura et al., Kagaku-no-ryoiki 30-2, 79-87; "Good's Buffer Development and Progress of New pH Buffers" (1976).

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