Method for preparing Mucuna pruriens seed extract

Details Method for preparing Mucuna pruriens seed extract Method for preparing Mucuna pruriens seed extract

2003-10-02

2008-12-30

Leith, Patricia (Department: 1655)

Drug, bio-affecting and body treating compositions

Plant material or plant extract of undetermined constitution...

Containing or obtained from leguminosae

Reexamination Certificate

active

07470441

ABSTRACT:
The present invention provides pharmaceutical compositions comprisingMucuna pruriensseeds or one or moreMucuna pruriensseed components, substances, fractions or mixtures or substances obtained therefrom. Furthermore, the invention relates to the use ofMucuna pruriensseed powder or one or moreMucuna prurienscomponents, substances, fractions or mixtures or substances obtained therefrom for the preparation of a pharmaceutical composition for preventing, alleviating or treating neurological diseases. Additionally, the invention relates to the use ofMucuna pruriensseeds for the preparation of a pharmaceutical composition for neuroprotection or neurostimulation and to methods of preparing extracts ofMucuna prurienswhich can be used for the preparation of a pharmaceutical composition for treating neurological diseases. Finally, the invention relates to the use ofMucuna pruriensseeds for the preparation of a pharmaceutical composition for the treatment of Parkinson's Disease to obtain a broader therapeutic window in L-Dopa therapy, to delay a need for combination therapy, to obtain an earlier onset and longer duration of L-Dopa efficacy, and to prevent or alleviate acute and chronic L-Dopa toxicity.

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1996. Mahajami et al. Bioavailability of L-DOPA from HP-200- a formulation of seed powder ofMucuna pruriens(Bak): a Pharmacokinteic and Pharmacodynamic Study. Phytotherapy Research, vol. 10, 254-256.
1997. Hussain et al.Mucuna pruriensproves more effective than L-DOPA in Parkinson's disease animal model. Phytotherapy Research, vol. 11, 419-423.
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1937. Damodaran et al. Isolation of 3,4-dihydroxyphenylalanine from the seeds ofMucuna pruriens. Biochemistry. 31. 2149-21512.
1954. Majumdar et al.Mucuna pruriensIV. Alkaloidal consituents and their derivatives. Indian Pharmacist. vol. 10 p. 79-84.
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