Method for preparing cyclic ureas and their use for the synthesi

Details Method for preparing cyclic ureas and their use for the synthesi Method for preparing cyclic ureas and their use for the synthesi

1994-06-30

1996-06-25

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

564502, C07D491056, C07C22100

Patent

active

055301240

ABSTRACT:
This invention provides improved synthetic processes for the preparation of hydroxy-protected cyclic urea compounds of Formula (IX), ##STR1## which are useful as intermediates for the preparation of cyclic urea human immunodeficiency virus (HIV) protease inhibitors, from N-protected aminoaldehydes. The processes of the present invention provide high yields, can be conducted on multikilogram scale, and eliminate the need for chromatographic purification of intermediates or final product.

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