Method for preparing cyanophosphonate derivatives from phosphate

Details Method for preparing cyanophosphonate derivatives from phosphate Method for preparing cyanophosphonate derivatives from phosphate

1997-12-23

1999-01-19

Ambrose, Michael G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

423302, 558145, 558166, 558167, 562 16, C07F 940, C07F 938

Patent

active

058615253

ABSTRACT:
A process for preparing cyanophosphonate derivatives involves contacting a phosphate ester and cyanide in a reaction mixture under conditions sufficient to produce a cyanophosphonate derivative. That cyanophosphonate derivative product can subsequently be hydrogenated to produce an aminomethylphosphonate derivative.

REFERENCES:
patent: 2402703 (1946-06-01), Woodstock
patent: 2702299 (1955-02-01), Harris
patent: 3432277 (1969-03-01), Roesky
patent: 3812221 (1974-05-01), Braden et al.
patent: 4221583 (1980-09-01), Gaertner et al.
patent: 4568432 (1986-02-01), Rogers
patent: 5128333 (1992-07-01), Fukuto et al.
Abstract-Database WPI, Section Ch, Week 7615, Derwent Publications Ltd., London, GB; Class B04, AN 76-27192X, XP002061354 & JP 51 023 225 A (Nippon Chem. Ind. Co. Ltd.), Feb. 24, 1976.
Blanchard, J. "Preparation d-acides beta-amino-ethyl-phosphoniques" Tetrahedron, vol. 32, No. 4, 1976, Oxford GB, pp. 455-459, XP002061374.
Chemical Abstracts, vol. 093, No. 12, Sep. 22, 1980, Columbus, Ohio, US; abstract No. 123612, Zhurba, Y.I. et al. "Increase in the stability of silver complexes in the process of simultaneous developing and fixing" and Zh Nauchn, Pirkl. Fotogr. Kinematogr. (ZNPFAG, 00444561); 80; vol. 25(3); pp. 182-185, Vses. Gos. Nauchno-Issled. Proektn. Inst. Khim.-Fotogr. Prom., Moscow; USSR; XP002061352.
Dyatkina, N. et al. Synthesis and antiviral activity of some fluorinated nucleotide derivativers: Nucleosides Nucleotides (Nunud5, 07328311); 94; col. 13 (1-3); pp. 325-337, Engelhardt Inst. Mol. Biol.; Mowcow; 117984, Russia XP002061348, 1994.
Kashemirov, B.A. "(E)-(Hydroxyimino)(hydroxymethoxyphosphinyl)acetic acid: Synthesis and pH dependent fragmentation," Tetrahedron Letters, vol. 36, No. 52, 1995, Oxford GB, pp. 9437-9440; XP002061351.
Albrecht et al., "Reaction of the Two-Component System Trialkyl Phosphite/Carbon Tetrachloride with Nucleophiles 3. Reaction in Presence of Trialkylammonium Salts," Z. anorg. allg. Chem.552: 132-146 (1987) and English language translation.
Kashemirov et al., "Troika Acids: Synthesis, Structure, and Fragmentation Pathways of Novel .alpha.-(Hydroxyimino)phosphonacetic Acids," J. Am. Chem. Soc.117: 7285-7286 (1995).
Shioiri et al., "Reaction of Diethyl Phosphorocyanidate(DEPC) with Carboxylic Acids. A New Synthesis of Carboxylic Esters and Amides," Tetrahedron32(18): 2211-2217 (1976).
Tung et al., "A New Method for the Preparation of O,O'-Dialkylphosphoryl Cyanides," Hua Hsueh Hsueh Pao (Acta Chimica Sinica)31(3): 199-202 (1965).

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