Method for preparing crystalline cefadroxil monohydrate

Details Method for preparing crystalline cefadroxil monohydrate Method for preparing crystalline cefadroxil monohydrate

1987-08-03

1990-02-06

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50122, A61K 31545

Patent

active

048989380

ABSTRACT:
The invention relates to a method for preparing crystalline cefadroxil monohydrate.
According to such a method a cefadroxil solvate is slurried with isopropyl alcohol containing less 6% to 18% of water at a temperature between +45.degree. to +55.degree. C.: the crystalline cefadroxil monohydrate is isolated by filtration.
Some of the cefadroxil solvates which can be used are novel: they are prepared by adding dimethylacetamide, N-methyl-2-pyrrolidone or monomethylformamide to an aqueous solution of cefadroxil at a pH between 5.5 and 6.

REFERENCES:
patent: 4234721 (1980-11-01), Bouzard et al.
patent: 4504657 (1985-03-01), Bouzard et al.

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