Method for preparing crystalline 3-0-alkyl-ascorbic acid

Details Method for preparing crystalline 3-0-alkyl-ascorbic acid Method for preparing crystalline 3-0-alkyl-ascorbic acid

2006-12-07

2010-11-23

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07838690

ABSTRACT:
The present invention relates to a method for preparing 3-O-substituted ascorbic acid derivatives represented by formula 1, in which 5,6-O-isopropylidene ascorbic acid is reacted with a halide in an organic solvent in the presence of the anion exchange resin absorbed with multi-iodine anions and then deprotected. The method of the present invention has an advantage of providing a target compound with high purity and high yield by finishing the reaction within a short period of time at room temperature.

REFERENCES:
patent: 4552888 (1985-11-01), Koppel et al.
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patent: 1020010070672 (2001-07-01), None
patent: 1020040088312 (2004-10-01), None
patent: 100600435 (2006-07-01), None
Kato et al.; “Studies on Scavengers of Active Oxygen Species. 1. Synthesis and Biological Activity of 2-O-Alkylascorbic Acids”; J. Med. Chem.; 1988; pp. 793-798; vol. 31.
Jackson et al.; “The C- and O-Benzylation of L-Ascorbic Acid”; Canadian Journal of Chemistry; 1965; pp. 450-457; vol. 43.

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