Method for preparing colloidal particles in the form of...

Details Method for preparing colloidal particles in the form of... Method for preparing colloidal particles in the form of...

2008-03-25

2008-03-25

Woodward, Michael P. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S489000, C424S400000

Reexamination Certificate

active

10203656

ABSTRACT:
The invention relates to a process for the preparation of dispersible colloidal systems in the form of nanocapsules whose wall consists of a polymer obtained by the polycondensation of two monomers, α and β, and whose core consists of a substance B, characterized in that:(1) a first liquid phase is prepared which consists of a solution of monomer α in a solvent or solvent mixture and contains one or more surfactants and the substance B in solution or suspension;(2) a second liquid phase is prepared which consists of a non-solvent or non-solvent mixture for the monomer α and contains the monomer β and one or more surfactants, the solvent or solvent mixture of the first phase being miscible in all proportions with the non-solvent or non-solvent mixture of the second phase;(3) the first phase is added to the second, with moderate agitation, to give a colloidal suspension of nanocapsules, agitation being maintained until the monomers α and β have completely polymerized; and(4) if desired, all or part of the solvent or solvent mixture and non-solvent or non-solvent mixture is removed to give a colloidal suspension having the desired concentration of nanocapsules.

REFERENCES:
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patent: 5174930 (1992-12-01), Stainmesse et al.
patent: 5500224 (1996-03-01), Vranckx
patent: 5783211 (1998-07-01), Manzo et al.
patent: 2766368 (1997-07-01), None
patent: 06-170214 (1994-06-01), None
patent: 07-116500 (1995-05-01), None
patent: 94/13139 (1994-06-01), None
patent: 94/15590 (1994-07-01), None
Derwent Acc No. 1986-335063 Apr. 28, 1986.

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