Method for preparing cephalosporin derivatives

Details Method for preparing cephalosporin derivatives Method for preparing cephalosporin derivatives

1994-04-20

1996-03-12

Rizzo, Nicholas

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540226, 540227, 540225, 540228, C07D50104

Patent

active

054987873

ABSTRACT:
A method for preparing cephalosporm derivatives by reacting cephalosporin alkaline metal salts with organic halide in the presence of quaternary ammonium salts catalyst is disclosed. .DELTA..sup.3 .fwdarw..DELTA..sup.2 isomerization, a side reaction commonly reported in preparation of cephalosporin derivatives was successfully eliminated. The desired .DELTA..sup.3 was obtained as a sole product in the reaction.

REFERENCES:
Demuth, T. P. et al., Journal of Antibiotics, 1991, 44(2), 200.
Mobashery et al., Journal of Org. Chemistry, 1986, 51, 4723.

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