Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-08-30
2005-08-30
Powers, Fiona T. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
06936720
ABSTRACT:
The present invention relates to a process of preparing benzisoxazole methane sulfonic acid-chloride (BOS—Cl) as an zonisamide intermediate via chlorination of benzisoxazole methane sulfonate. The present invention also discloses a process of preparing zonisamide via amidation of BOS—Cl. More particularly, the present invention provides a process of preparing zonisamide, comprising the steps of: a) chlorinating BOS, salts or esters thereof, with SOCl2in an organic solvent and/or in the presence of a catalyst to form BOS—Cl; and b) amidating BOS—Cl in the presence of ammonia selected from the group consisting of aqueous ammonia in a biphasic system, masked ammonia and dry ammonia to form zonisamide.
REFERENCES:
patent: 4172896 (1979-10-01), Uno et al.
patent: 6677458 (2004-01-01), Mendelovici et al.
patent: 53-77057 (1978-07-01), None
Gershon Neomi
Mendelovici Marioara
Nidam Tamar
Pilarski Gideon
Sterinbaum Greta
Kenyon & Kenyon
Powers Fiona T.
Teva Pharmaceutical Industries Ltd.
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