Method for preparing auranofin

Details Method for preparing auranofin Method for preparing auranofin

1977-04-21

1978-12-26

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 4, 536122, C07H 510

Patent

active

041317327

ABSTRACT:
A new synthesis of auranofin comprising reacting 2,3,4,6-tetra-O-acetyl-.alpha.-D-glucopyranosyl bromide with triethylphosphinegold(I) chloride and sodium or potassiumsulfide. Auranofin is an antiarthritic pharmaceutical compound. Auranofin is an orally active therapeutic agent which is useful in man as an antiarthritic.

REFERENCES:
patent: 3635945 (1972-01-01), Nemeth et al.
Sutton, "Jour. of Medicinal Chem." vol. 15, No. 11, 1972, pp. 1095-1098.
Noller "Chem. of Organic Cpds." 3rd Ed. W. B. Saunders, Co. Phila., Pa. 1965, pp. 304-307.

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