Method for preparing antihypertensive agent

Details Method for preparing antihypertensive agent Method for preparing antihypertensive agent

1997-07-25

1998-12-29

Tsang, Cecilia J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

514 19, 530800, C12P 2102, A61K 3805, C07K 506

Patent

active

058540296

ABSTRACT:
An antihypertensive agent containing an effective amount of dipeptide Tyr-Pro and/or a pharmaceutically acceptable salt thereof, the effective amount being from 0.05 to 10 mg/kg body weight/day, and a method for producing the same.

REFERENCES:
Maher, T., et al. Use of parenteral dipeptides to increase serum tyrosine levels and to enhance catecholamine-mediated neurotransmission. J. Pharm. Sci. 79(8):685-7, Aug. 1990.
Miyakawa, H., et al. Purification and characterization of an X-prolyl dipeptidyl aminopeptidase from Lactobacillus helveticus LHE-511. Milchwissenschaft. 49(12):670-3, Dec. 1994.

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