Food or edible material: processes – compositions – and products – Building up units from diverse edible particulate material...
Patent
1988-08-16
1990-11-06
Paden, Carolyn
Food or edible material: processes, compositions, and products
Building up units from diverse edible particulate material...
426477, 426591, A23P 102
Patent
active
049685171
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
The invention concerns a method for preparing an effervescent granulate including Carnitine an effervescent granulate made accordingly, and its utilization.
The desirable addition of the vitaminlike compound L-Carnitine which plays an important part in the human metabolism, to obtain effervescent granulates, is not practicable due to the high hygroscopicity of this substance, up to the present time. L-Carnitine performs an essential function for the utilization of fatty acids and for the transport of metabolic energy.
The betaine character, that is the formation of an internal salt between the positively charged nitrogen and the negatively charged COO group in Carnitine is the reason for its ability to react on acids and its high hygroscopicity. Therefore, the commercially available pharmaceutical Carnitine preparations mix Carnitine with inert substances in order to prevent the possibilities of reaction. Mainly inert substances have also been suggested for tablet pressing. However, due to the volume it is hardly any longer possible to use large dosages such as for example the oral administration of e.g. 1 g of Carnitine in the form of a tablet. Also a dilution with sugar, carbohydrates and other inert substances for the purpose of establishing a base for preparing a drinking solution results in too large a volume total and too high weights. This base is not acceptable in terms of taste and not economical.
But efforts are made to dissolve these large dosages in water before taking the preparation.
But this modern form of administration designed for larger dosages of active pharmaceutical substances should dissolve fast and in the form of a tasty beverage. However, such preparations require, as is known, an acceptable taste, besides a fast dissolution, due to organic acids of the type of tartaric acid, citric acid, malic acid etc. as well as carbonates or bicarbonates of the type of sodium carbonate, calcium carbonate etc.
When L-Carnitine comes into contact with organic acids, acid salts are formed, as described in the EP-0-0 150 688, which are said to have a by far lower hygroscopicity than L-Carnitine proper. However, these acid salts must now be insulated at this stage, because otherwise they will continue to react with the organic acid finally resulting in a glassy still much more hygroscopic structure than the L-Carnitin proper.
SUMMARY OF THE INVENTION
Therefore, the invention is based on the problem to obtain stable types of administration with organic acids despite the acid activity of L-Carnitine, which must be stable in terms of temperature, and have little hygroscopy, but dissolve fast in water.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
According to the invention this problem is solved by the method of manufacture of effervescent granulates which includes the steps of preparing: a preliminary solution with organic acid, alkaline earth or alkaline earth metal carbonate and solvent; applying the preliminary solution onto organic acid crystals; applying a salt onto the acid crystals which have been moistened with the preliminary reactive solution; adding a pulverized coating; drying the coated crystals and adding L-Carnitine. The foregoing method is an improvement over the process described in German Pat. Application No. P 36 27 475.5-41.
Other specific features of this invention include the use of citric acid as the organic acid, the use of vacuum in the method, the use of a solvent in the preparation of the preliminary solution which is either alcohol or water, the use of anhydrous sodium carbonate as the alkaline metal carbonate, the adding of L-Carnitine in the amount of 15-30 percent by weight with the amount of 20-25 percent being preferred, the utilization of the granulate, preparing an effervescent beverage or in the use of preparing effervescent tablet.
Through the passivation of the surface of the organic acid crystals proposed by the invention it is possible to prevent their influence on the L-Carnitine while the additional drying function of the outer l
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patent: 4602039 (1986-09-01), Cavazza
patent: 4687782 (1987-08-01), Brantman
patent: 4753804 (1988-06-01), Iaccheri
Gergely Gerhard
Gergely Irmgard
Gergely Thomas
Wolf Ruediger
Gergely Gerhard
Paden Carolyn
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