Method for preparing .alpha.-L-aspartyl-L-phenylalanine

Details Method for preparing .alpha.-L-aspartyl-L-phenylalanine Method for preparing .alpha.-L-aspartyl-L-phenylalanine

1993-11-16

1994-11-08

Dees, Jose' G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562450, C07C10352

Patent

active

053629035

ABSTRACT:
This invention is directed to provide a method for obtaining .alpha.-L-aspartyl-L-phenylalanine selectively in high yields. Diffusion dialysis with an ion exchange membrane is used to decrease hydrochloric acid concentration of a mixed solution containing hydrochloric acid and one or more of four .alpha.-L-aspartyl-L-phenylalanine derivatives, i.e., .alpha.-L-aspartyl-L-phenylalanine methyl ester, .alpha.-L-aspartyl-L-phenylalanine, .alpha.-L-aspartyl-L-phenylalanine-.beta.-methyl ester and .alpha.-L-aspartyl-L-phenylalanine dimethyl ester. The resultant solution is concentrated, to which a base is added for neutralization. Subsequently, .alpha.-L-aspartyl-L-phenylalanine is crystallized and isolated.

REFERENCES:
patent: 4634790 (1987-01-01), Shinohara et al.
patent: 4822907 (1989-04-01), Sugiyama
patent: 5062960 (1991-11-01), Aoki
CA119:52368; 1992.

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