Method for preparing adenosine triphosphate

Details Method for preparing adenosine triphosphate Method for preparing adenosine triphosphate

1977-01-31

1979-08-14

Brown,

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

2605012, 260545P, 260987, 536 27, 536 28, 536 29, C12D 1306, C07H 1920

Patent

active

041644441

ABSTRACT:
Acyl phosphate salts suitable for use as phosphate donors in the production of cofactors, such as adenosine triphosphate, are prepared by acylation of phosphoric acid with a ketene, followed by reaction with ammonia or an amine. The reaction product, e.g. diammonium acetyl phosphate, can normally be used directly in enzymic production of cofactors without the necessity of prior conversion to the free acid or another salt, such as the sodium salt. The acyl phosphate salts are produced in high yields, and the method allows production of cofactors for use in biosynthesis from readily available materials.

REFERENCES:
patent: 3079379 (1963-02-01), Tanaka et al.
patent: 3188309 (1965-06-01), Mukaiyama et al.
patent: 3188310 (1965-06-01), Mukaiyama et al.
patent: 3321463 (1967-05-01), Moffatt
patent: 3594278 (1971-07-01), Naylor
patent: 3779867 (1973-12-01), Katoh et al.
patent: 3878194 (1975-04-01), Moffatt et al.

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