Method for preparing a purified extraction residue fraction and

Details Method for preparing a purified extraction residue fraction and Method for preparing a purified extraction residue fraction and

1981-04-20

1983-10-18

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 435253, A61K 3902, C12N 120

Patent

active

044105100

ABSTRACT:
A method is disclosed for preparing a purified extraction residue fraction (antigen) of a microorganism isolated from the blood or urine of a warm-blooded animal or tumor carried by a warm-blooded animal, the microorganism having the capacity to synthesize the polypeptide hormone known as "chorionic gonadotropin" in its total form or in its alpha and beta subunits. The purified extraction residue fraction is an activator and modulator of immunological response and is capable of evoking pronounced prophylactic and therapeutic effects against a variety of tumors in laboratory animals and man. The immune response is stimulated by administering an effective immunostimulating amount of the residue fraction.

REFERENCES:
patent: 3958025 (1976-05-01), Livingston
Livingston et al., Trans. N.Y. Acad. Sci., vol. 36, p. 569 (1974).
Cohen et al., Proc. Soc. Exp. Biol. and Med., vol. 152, pp. 408-410 (1976).
Maruo et al., Proc. Natl. Acad. Sci., vol. 76, pp. 6622-6626, 1979.
Acevedo et al., Cancer, vol. 41, pp. 1217-1229, 1978.
Acevedo et al., Infection and Immunity, vol. 24, pp. 920-924, 1979.

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