Method for preparing a phosphonic acid ester

Details Method for preparing a phosphonic acid ester Method for preparing a phosphonic acid ester

1989-07-17

1993-01-05

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

556404, 558155, 558161, 562 21, C07F 940, C07F 708

Patent

active

051772396

ABSTRACT:
A method is provided for preparing a phosphonic acid ester having the structure ##STR1## wherein R.sup.1 is farnesyl or a derivative or analog thereof, and R.sup.2 is lower alkyl, by treating a farnesyl halide R.sup.1 Hal(Hal.dbd.Cl,Br,I) with an alkoxide of the structure ##STR2## wherein M is an alkali metal and R.sup.2c is lower alkyl. The resulting phosphonic acid ester is an intermediate in preparing a squalene synthetase inhibitor which is used for inhibiting cholesterol biosynthesis.

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