Method for preparing a macromolecular monoclonal antibody compos

Details Method for preparing a macromolecular monoclonal antibody compos Method for preparing a macromolecular monoclonal antibody compos

1986-10-10

1989-09-05

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Lymphokine

424 8591, 424 78, 424450, 530387, 530389, 530390, 530391, 530402, 530403, 530404, 530405, 530813, 530816, 530817, 514 23, 514 54, 435 68, 435 69, 436529, 436532, 436535, 436829, A61K 39395, C07K 300, C07K 1706, C07K 1710

Patent

active

048637297

ABSTRACT:
Macromolecular monoclonal antibody compositions are provided which are capable of selectively forming stable bonds to cells having a predetermined concentration of at least one surface antigen, such concentration being greater in such cells than in other cells in the cell population, wherein the composition comprises a substrate and a plurality of monoclonal antibodies specific to said surface antigen or antigens, which antibodies are covalently bonded to the substrate.

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patent: 4673734 (1987-06-01), Tayot et al.
patent: 4698420 (1987-10-01), Urnowitz
Ho et al., Biochemistry 25, 1986, pp. 550-06.
Costello et al., Clin. Chem. 25(4) 1979, pp. 1572-1580.
Leserman et al., Targeting to Cells of Fluorescent Liposomes Covalently Coupled with Monoclonal Antibody or Protein A, Nature 288, 602-604.
Vogel et al., Induction of Immune Cytolysis, Proc. Natl. Acad. Sci. USA 78(12), 7707-7711 (Dec. 1981).
Dippold et al., Cell Surface Antigens of Human Malignant Melanoma, Proc Natl. Acad. Sci. U.S.A. 77(10), 6114-6118 (Oct. 1980).

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