Method for preparing a heat-stable plasma protein solution from

Details Method for preparing a heat-stable plasma protein solution from Method for preparing a heat-stable plasma protein solution from

1974-06-12

1977-04-12

Anderson, Harold D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260122, 424101, C07G 700

Patent

active

040174700

ABSTRACT:
A heat-stable plasma protein solution showing no blood pressure-depressing action is obtained by adding distilled water to a paste IV-1, a waste fraction obtained from the Cohn's cold ethanol plasma fractionation method and has heretofore been discarded as a waste, to extract water-soluble proteins in the paste, heat-treating the extract at pH 4.5 to 5.5 at 50.degree. to 65.degree. C. in the presence of an organic acid to remove as precipitates lipo- and glyco-proteins contained in the extract, adding Rivanol to the resulting supernatant to remove by precipitation residual lipo-proteins giving turbidity to the supernatant, and then removing blood pressure-depressing substances present in the resulting supernatant by adsorption with an inorganic adsorbent or cation exchanger. The thus obtained heat-stable plasma protein solution shows prominent effects in the therapy of shock by acute bleeding, burns, supply of protein nutrients, hypoproteinemia, etc., and is useful for medical treatments.

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patent: 2761811 (1956-09-01), Kupferberg et al.
patent: 2765299 (1956-10-01), Porsche et al.
patent: 2958628 (1960-11-01), Hink
patent: 3100737 (1963-08-01), Auerswaid et al.
patent: 3382227 (1968-05-01), West et al.
Chem-Abstracts, vol. 80, 1974, Izaka et al. -- 874999t, effective date Jan. 17, 1974.
Exp. Immunochemistry, Kabat et al.--pp. 763-765 and 768-773, 1961.

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