Method for preparing a crystalline polymorph of terazosin monohy

Details Method for preparing a crystalline polymorph of terazosin monohy Method for preparing a crystalline polymorph of terazosin monohy

1998-06-10

1999-09-28

Ambrose, Michael G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D24104

Patent

active

059591080

ABSTRACT:
A crystalline polymorphous terazosine monohydrochloride is obtained by suspending and treating a crystalline addition product of terazosine hydrochloride and methanol in a polar solvent which is an alcohol with 2 to 6 carbon atoms or a ketone with 2 to 6 carbon atoms or a mixture thereof. The thus obtained crystalline polymorphous terazosine hydrochloride is characterized by a reduced hygroscopicity and solvent residue retention capacity.

REFERENCES:
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patent: 5362730 (1994-11-01), Bauer et al.
patent: 5412095 (1995-05-01), Morley et al.
patent: 5504207 (1996-04-01), Mannino et al.
patent: 5587377 (1996-12-01), Patel et al.
Chem. Abstracts, vol. 119, No. 28, 1993.

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