Method for preparing a core material containment system and the

Details Method for preparing a core material containment system and the Method for preparing a core material containment system and the

1998-08-27

2000-05-09

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424456, 424451, 514962, 428 402, 428 405, 4272133, 427212, 264 4, A61K 966, A61K 948, A61K 964

Patent

active

060600845

ABSTRACT:
A method for preparing a core material containment system which prevents or controls leaching of the core material from the containment system, said method comprising the steps of: (1) providing a shell material having a softening temperature above about 70.degree. F.; (2) heating said shell material to a temperature at or above the softening temperature of said shell material; (3) adding an oil to the molten shell material, said oil being compatible with said shell material but not a solvent for the shell material in a solid state; (4) uniformly dispersing a core material in the molten, oil-containing shell material; (5) subdividing said molten, oil-containing shell material having said core material dispersed therein into individual droplets of a predetermined size; (6) cooling the molten, oil-containing shell material having said core material dispersed therein to a temperature below its softening temperature to obtain a plurality of encapsulated or coated particles of said core material; and (7) recovering said particles of encapsulated or coated core material; and a core material containment system prepared by such method are described.

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