Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-05-27
1994-07-26
Ramsuer, Robert W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
549306, C07D49308
Patent
active
053328400
ABSTRACT:
A method is provided for preparing a chiral benzaldehyde of the structure ##STR1## by acylating an anhydride of the structure ##STR2## with a chiral oxazolidine of the structure ##STR3## where Q is MgHal or Li, and X, Y and Z are as described herein, to form a keto acid which is reduced and cyclized. The resulting benzaldehyde may be used in making the final anti-thrombotic - anti-vasospastic compounds. Novel intermediates are also provided.
REFERENCES:
patent: 5100889 (1992-03-01), Misra et al.
Agami, C. et al "Kinetic Control of Asymmetric Induction During Oxazolidine Formation from (-)-Ephedrine and Aromatic Aldehydes", Tetrahedron vol. 41, No. 3, pp. 537-540, (1985).
Takahashi, H. et al "A New Asymmetric Synthesis of (R)- and (S)-3-Arylphthalides: Extremely High Diastereoselective Reaction of Arylcarbaldehydes with Chiral [2-(1,3-Oxazolidin-2-yl)phenyl]titanium Ate Complexes", Synthesis pp. 681-682, Jul. 1992.
Kronenthal David R.
Real Sharon D.
Bristol--Myers Squibb Company
Haley Jacqueline
Ramsuer Robert W.
Rodney Burton
LandOfFree
Method for preparing a benzaldehyde intermediate does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for preparing a benzaldehyde intermediate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for preparing a benzaldehyde intermediate will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1054125