Method for preparing a 7-quinolinyl-3,5-dihydroxyhept-6-enoate

Details Method for preparing a 7-quinolinyl-3,5-dihydroxyhept-6-enoate Method for preparing a 7-quinolinyl-3,5-dihydroxyhept-6-enoate

2006-05-02

2006-05-02

Powers, Fiona T. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07038056

ABSTRACT:
A method for preparing a 7-quinolynyl-3,5-dihydroxyhept-6-enoate useful as an intermediate for pharmaceuticals, in high yield and in high purity, is presented. It is a method for preparing a 7-quinolinyl-3,5-dihydroxyhept-6-enoate represented by the formula (IV):(wherein R represents an alkyl group or an aryl group), characterized in that a compound represented by the formula (I):(wherein R is as defined above), or a compound represented by the formula (II):(wherein R is as defined above), is reduced by sodium borohydride in the presence of a boron compound represented by the formula (III):in-line-formulae description="In-line Formulae" end="lead"?R′OBR″2  (III)in-line-formulae description="In-line Formulae" end="tail"?(wherein R′ and R″ represent independently an alkyl group), and then the resultant reaction mixture is treated with an aqueous solution of hydrogen peroxide.

REFERENCES:
patent: 4645854 (1987-02-01), Verhoeven et al.
patent: 5011930 (1991-04-01), Fujikawa et al.
patent: 5284953 (1994-02-01), Ohara et al.
patent: 5753675 (1998-05-01), Wattanasin
patent: 6946557 (2005-09-01), Onishi et al.
patent: 2004/0030139 (2004-02-01), Hara et al.
patent: 164049 (1985-12-01), None
patent: 304063 (1989-02-01), None
patent: 08-092217 (1996-01-01), None
patent: 08-092217 (1996-04-01), None
patent: WO 99/32434 (1999-07-01), None
English Translation of JP 08-92217, Apr. 9, 1996.
Koichi Narasaka et al.: “Steroselective synthesis of meso(or erythro) 1, 3-diols from beta-hydroxyketones” Chemistry Letters, pp. 1415-1418, 1980.
Mikio Suzuki, et al., “Synthesis and Biological Evaluations of Quinoline-based HMG-CoA Reductase Inductors”, Bioorganic & Medicinal Chemistry, vol. 9, No. 10, XP-002313788, 2001, pp. 2727-2743.
Koichi Narasaka et al.: “Stereoselective synthesis of meso(or erythro) 1, 3-diols from beta-hydroxyketones” Chemistry Letters, pp. 1415-1418. 1980
Kau-Ming Chen et al. “A Novel Method for the In Situ Generation of Alkoxydialkylobranes and Their Use in the Selective Preparation of 1, 3-Syn Diols” Chemistry Letters, pp. 1923-1926. 1987

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