Method for preparing 7.alpha.-acylthio-4-en-3-oxosteroids

Details Method for preparing 7.alpha.-acylthio-4-en-3-oxosteroids Method for preparing 7.alpha.-acylthio-4-en-3-oxosteroids

1981-03-05

1982-04-06

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 1700

Patent

active

043235000

ABSTRACT:
A 7.alpha.-acylthio-4-en-3-oxosteroid such as 7.alpha.-acetylthio-17-hydroxy-3-oxo-17.alpha.-pregn-4-ene-21-carboxylic acid .gamma.-lactone (spironolactone) which is an antialdosteronic diuretic effective in therapy is prepared by contacting a steroidal material which contains a 7.beta.-acylthio-4-en-3-oxosteroid with a thiocarboxylic acid.

REFERENCES:
patent: 3883512 (1975-05-01), Stache et al.
patent: 4211701 (1980-07-01), Temko
patent: 4265816 (1981-05-01), Okushima et al.

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