Method for preparing 4-hydroxyphenylacetic acid

Details Method for preparing 4-hydroxyphenylacetic acid Method for preparing 4-hydroxyphenylacetic acid

1982-03-02

1983-10-25

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

568630, 568631, 568647, 568655, 260465F, C07C 6501

Patent

active

044120826

ABSTRACT:
A novel process for preparing 4-hydroxyphenylacetic acid which is useful as an intermediate for pharmaceutical is provided. A method for preparing 4-hydroxyphenylacetic acid comprising the steps of first reacting benzyl phenyl ether with formaldehyde and hydrogen chloride to form 4-benzyloxybenzyl chloride, second reacting the resultant 4-benzyloxybenzyl chloride with an alkali metal cyanide in at least one solvent selected from the group consisting of water and an organic solvent to form 4-benzyloxyphenylacetonitrile, and hydrolyzing the resultant 4-benzyloxyphenylacetonitrile in the presence of an acid catalyst.

REFERENCES:
patent: 4178460 (1979-12-01), Berkelhammer et al.

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