Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and d

Details Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and d Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and d

1990-11-02

1992-09-08

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546187, 546190, 546191, 546193, 546194, 546196, 546197, 546198, 546199, 546200, 546201, 546202, 546209, 546210, 546211, 546212, 546213, 546223, 546224, 544323, 544326, 544324, 544227, 544284, C07D40104

Patent

active

051459671

ABSTRACT:
The present invention is directed to a method for preparing a 4-alkoxyalkyl-4-phenylaminopiperidine compound which comprises the steps of (a) reacting an N-substituted-4-piperidone compound with an aniline compound to form a Schiff base compound, (b) reacting the Schiff base compound with an anionic reagent having an anion stabilizing group to form an amine compound, and (c) reducing the amine compound in step (b) with a reducing agent to displace the anion stabilizing group.
The anionic reagent in step (b) above has the general formula:

REFERENCES:
patent: 3164600 (1965-01-01), Jannsen
patent: 3998834 (1976-12-01), Jannsen et al.
patent: 4584303 (1986-04-01), Huang et al.
patent: 4791120 (1988-12-01), Lin et al.
J. March, "Advanced Organic Chemistry", 2nd ed., p.666, McGraw-Hill, New York (1977).
E. E. Smissman et al., J. Org. Chem., "Thiomethylation", 35 (5), 1357-1360 (1970).
C. G. Gutierrez et al., J. Org. Chem., "Tri-n-Butyl Tin Hydride", 45 (17), 3393-3395 (1980).
V. H. Rawal et al., Synthetic Communications 14, (1984), pp. 1129-1139.
A. H. Becket et al., J. Med. Pharm. Chem., vol. 1, (1959), pp. 37-58.
C. R. Ganellin et al., J. Med. Chem., vol.8, (1965), pp. 619-625.
P. M. Carabateas et al., J. Med. Pharm Chem., vol. 5, (1962), pp. 913-919.
P. Van Daele et al., Arzneim-Forsch. Drug Res., vol.26, (1976), pp. 1521-1531.
R. A. Olofson et al., J. Org. Chem., vol. 49, (1984), pp. 2081.sub.]2082.

Affiliated with

Also associated with

Rating

Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and d does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and d, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and d will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-135219