Method for preparing (+)-(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2

Details Method for preparing (+)-(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2 Method for preparing (+)-(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2

1993-04-29

1995-05-09

Rizzo, Nicholas

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D26702

Patent

active

RE0349356

ABSTRACT:
2-Aminothiophenol is reacted with methyl (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)propionate, and the intermediate methyl (2S,3S)-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)propionate is cyclized in the presence of methanesulfonic acid, in the same vessel and without isolating said intermediate product, using e.g. chlorobenzene as a solvent.

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Hashiyama et al., "Reaction of 3-Phenylglycidic Esters" Part 2, J. Chem. Soc. Perkin. Trans. 1:421-427, (1985).

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