Method for preparing (2S, 3R, 4S)-4-hydroxyisoleucine and...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...

Reexamination Certificate

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C435S106000, C435S041000

Reexamination Certificate

active

07432087

ABSTRACT:
The invention concerns a method for preparing a-amino acids of general formula (2S-1) wherein: the group R1 represents a hydrogen atom, a group protecting the amino group or a group of formula —COOR2 wherein the group R2 represents a C1-C6 alkyl group, an aryl or aralkyl group. The invention also concerns a-amino acids of general formula (2S-1) wherein the group R1 represents a group protecting the amino group or a group of formula —COOR2 wherein the group R2 represents a C1-C6 alkyl group, an aryl or aralkyl group and their use as medicine.

REFERENCES:
patent: WO 97/32577 (1997-09-01), None
Kawai et al., 1994, Tetrahedron Letters, 35, 147-8 □□.
Anelli et al., 1987, J. Org. Chem., 52, 2559-62 □□.
Ishitani et al., Jan. 25, 2000, J. Am. Chem. Soc., 122, 762-6.
XP 000610220; Alcock et al., Stereochemistry of the 4-Hydroxyisoleucine From Trigonella Foenum-Graecum; Phytochemistry, vol. 28. No. 7, pp. 1835-1841, 1989.
XP 002156490; Hasan et al., Die Vier Diastereomeren y-Hydroxyisoleucinlactone; Liebigs Ann. Chem. 1976; pp. 781-787 (Abstract Only).
XP 002156491; Gieren et al.; Die Konfiguration Der Hydroxylierten Isoleucine Der Amatoxine; Liebigs Ann. Chem.; 1974; pp. 1561-1569 (Abstract Only).
XP 002020594; Petit et al., PS 8 Insulin Secretion In Vitro (Abstract Only).
Kawai et al., Stereoselective Synthesis of Ethyl (2S, 3S)-Anti-2-Methyl-3-Hydroxybutanoate Mediated by an Oxidoreductase From Geotrichum Candidum, vol. 35, Issue 1, Jan. 3, 1994, pp. 147-148 (Abstract Only).
Zheng et al., Asymmetric Reduction of Ketoesters With Alcohol Dehydrogenase From Thermoanaerobacter Ethanolicus, Bioorganic & Medicinal Chemistry Letters, vol. 2 Issue 6, Jun. 1992, pp. 619-622 (Abstract Only).

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