Method for preparing 2-methyl-1,4-naphthoquinone (vitamin K.sub.

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

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C07C 4600

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057707740

ABSTRACT:
A method for preparing 2-methyl-1,4-naphthoquinone (vitamin K.sub.3), in which 2-methyl-1,4-benzoquinone and 1,3-butadienes are subjected to a using dimethylsulfoxide as both a dehydrogenating agent and a solvent in the presence of at least one Lewis acid or a Broensted acid, in a single pot, shows high selectivity and yield.

REFERENCES:
Chem Rev 1993, 93, 741-761 Pindur "Acceleration & Selectivity Enhancement of Diels Alder Raction, et".
Liebigs Ann. Chem 1993 905-909 Khanbabaee "Total Synthesis of Hallachrome et al".
Sigma Chem Cataloge 1996 p. 688.

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