Method for preparing 2- (2-pyridylmethylsulphinyl)...

Details Method for preparing 2- (2-pyridylmethylsulphinyl)... Method for preparing 2- (2-pyridylmethylsulphinyl)...

2006-06-20

2006-06-20

Morris, Patricia L. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07064213

ABSTRACT:
The present invention provides a method for preparing an antiulcer agent, 2-(2-pyridylmethylsulphinyl)benzimidazoles, such as Omeprazole, Lansoprazole and Pantoprazole, which includes oxidizing an intermediate having a linkage of methylthio group (—CH2S—) to methylsulfinyl (—CH2S(O)—) in the presence of an oxidation catalyst of acetyl acetonate of molybdenium (II) [(CH3C(O)CH2C(O)CH2)2Mo].

REFERENCES:
patent: 5374730 (1994-12-01), Slemon et al.
patent: 2004/0138466 (2004-07-01), Avrutov et al.
patent: 2063705 (1993-06-01), None
Rouchard et al., “Catalysis of the oxidation, etc.,” Bulletin de la Societe Chimque de France (1980), 9-10, Pr. 2, pp. 441-443.
Bortolini et al., “Metal catalysts in oxidation etc.,” CA 97: 55094 (1982).

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