Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1976-03-29
1978-09-12
Roberts, Elbert L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
26023955R, C07J 500
Patent
active
041136802
ABSTRACT:
One-step method for preparing 17 .alpha.-ester-21-halo pregnanes by reacting 17 .alpha., 21-cyclic orthoesters of 17 .alpha., 21-dihydroxy pregnanes with a halo compound in the presence of an organic polar solvent, simultaneously resulting in halogenation at 21-position and esterification at 17 .alpha.-position of said 17 .alpha., 21-cyclic orthoesters, the reaction proceeding in a short period of time without, or substantially without, any unfavorable side-reactions.
REFERENCES:
patent: 3826366 (1974-08-01), Cimarusti
patent: 3992422 (1976-11-01), Green
Kamano Yoshiaki
Michishita Kazuhiko
Seki Teruya
Tanaka Ichiro
Roberts Elbert L.
Taisho Pharmaceutical Co. Ltd.
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