Method for preparing 17 .alpha.-ester-21-halo pregnanes

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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26023955R, C07J 500

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active

041136802

ABSTRACT:
One-step method for preparing 17 .alpha.-ester-21-halo pregnanes by reacting 17 .alpha., 21-cyclic orthoesters of 17 .alpha., 21-dihydroxy pregnanes with a halo compound in the presence of an organic polar solvent, simultaneously resulting in halogenation at 21-position and esterification at 17 .alpha.-position of said 17 .alpha., 21-cyclic orthoesters, the reaction proceeding in a short period of time without, or substantially without, any unfavorable side-reactions.

REFERENCES:
patent: 3826366 (1974-08-01), Cimarusti
patent: 3992422 (1976-11-01), Green

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