Method for preparing 10,10-difluoro prostacyclin intermediates a

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

542429, 560120, 568819, C07D307935

Patent

active

043116442

ABSTRACT:
A method is provided for preparing intermediates for use in 10,10-difluoro prostacyclin syntheses which method includes the steps of aceylating ketopinic acid or its acid halide to form the corresponding ketopinoyl diene ester intermediate, subjecting the diene ester to a Diels-Alder reaction by reacting same with cyclopentendione, subjecting the resulting chiral ester intermediate to a fluorination and reduction to form the corresponding chiral ester diol intermediate, subjecting the diol to solvolysis to form the chiral triol intermediate, hydroxylating the chiral triol to form a pentol intermediate, subjecting the pentol to a ring cleavage to form the difluoro dihydroxy prostacyclin intermediate ##STR1## and subjecting same to a Wittig reaction to form the difluoro dihydroxy prostacyclin intermediate ##STR2## All of the above-mentioned intermediates are novel compounds and thus are also provided.

REFERENCES:
Fried et al., "10,10-Difluoro-1,3-dehydroprostacyclin: A Chemically and Metabolically Stabilized Potent Prostacyclin", J. Med. Chem. 1980, 23, 234-237.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for preparing 10,10-difluoro prostacyclin intermediates a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for preparing 10,10-difluoro prostacyclin intermediates a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for preparing 10,10-difluoro prostacyclin intermediates a will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1914735

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.