Method for preparation of tertiary-hydrocarbylsilyl compounds

Details Method for preparation of tertiary-hydrocarbylsilyl compounds Method for preparation of tertiary-hydrocarbylsilyl compounds

1998-06-11

1999-02-16

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

C07F 708

Patent

active

058722742

ABSTRACT:
A method for the preparation of tertiary-hydrocarbylsilyl compounds. The method comprises contacting a mixture comprising diethylene glycol dibutyl ether, and a Grignard reagent described by formula RMgX with a silicon compound described by formula R.sup.1.sub.a SiX.sub.4-a, where R is a tertiary-hydrocarbyl group comprising four to about 20 carbon atoms, each R.sup.1 is an independently selected substituted or unsubstituted monovalent hydrocarbon group comprising one to about 20 carbon atoms, each X is an independently selected halogen atom, and a is an integer with a value of zero to three, in the presence of an effective amount of a copper compound catalyst. The present invention provides a method for making sterically hindered organosilicon intermediates useful in the pharmaceutical industry.

REFERENCES:
patent: 2902504 (1959-09-01), Nitzsche et al.
patent: 5068386 (1991-11-01), Shirahata
patent: 5294727 (1994-03-01), Kubota et al.
patent: 5629439 (1997-05-01), Nank et al.
patent: 5756796 (1998-05-01), Davern et al.

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