Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters
Patent
1994-02-14
1995-07-04
Lee, Mary C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus esters
558119, 558122, 558131, C07F 909
Patent
active
054301696
ABSTRACT:
The present invention provides a series of non-toxic compounds which function to inhibit the activity of S-1-P aldolase in respect to its cleavage of S-1-P. These inhibitors are described by the compounds of formula I ##STR1## wherein R is a radical containing 1 to 15 carbon atoms, a halogen, or hydrocarbon, R' is an organic radical or hydrogen, and R" is --NH.sub.3.sup.+ or --NH--NH .sup.+, with the proviso that, when R is CH.sub.3 (CH).sub.12 (CH.dbd.CH) and R' is hydrogen, R" is --NH--NH.sub.3.sup.+.
A method for preparing such compounds, which may generally be described as 1-phosphate derivatives of compounds which include a 2-amino-1,3-alcohol radical is also disclosed.
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Boumendjel Ahcene
Miller Stephen P. F.
Ambrose Michael G.
Lee Mary C.
The United States of America represented by the Department of He
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