Method for preparation of (S)-(+)- and...

Details Method for preparation of (S)-(+)- and... Method for preparation of (S)-(+)- and...

2006-09-25

2010-10-26

Coleman, Brenda L (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

07820813

ABSTRACT:
An efficient and high-yielding method for the preparation of optically pure (S)-(+)-10,11 -dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide and (R)-(−)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide by resolution of racemic (±)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide using a tartaric acid anhydride.

REFERENCES:
patent: 5451687 (1995-09-01), Sato et al.
patent: 7119197 (2006-10-01), Learmonth
patent: 0 751 129 (1997-01-01), None
patent: 10-087536 (1998-04-01), None
patent: 10-139732 (1998-05-01), None
patent: WO 97/01742 (1997-01-01), None
patent: WO 97/38978 (1997-10-01), None
Jan Benes et al.: “Anticonvulsant and Sodium Channel-Blocking Properties of Novel 10, 11-Dihydro-5H-Dibenz(b,f)Azephine-5-Carboxamide Derivatives,” J. Med. Chem., Am. Chem. Soc., vol. 42,1999, pp. 2582-2587.
English language abstract of JP 10-139732 (1998).
English language abstract of JP 10-087536 (1998).

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