Method for preparation of pure hepatitis B surface antigen from

Details Method for preparation of pure hepatitis B surface antigen from Method for preparation of pure hepatitis B surface antigen from

1982-06-07

1985-12-10

Hazel, Blondel

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Treating animal or plant material or micro-organism

424 88, 424 89, 260112R, 435 68, C07G 700, A61K 3929

Patent

active

045580111

ABSTRACT:
Method for preparation of pure hepatitis B surface antigen HBsAg from human plasma, wherein the initial plasma after being treated to remove lipides and partially remove human plasma proteins, is submitted to digestion with pepsin in amount of 0.01-0.50 mg/mg of protein to selectively decompose the plasma proteins while the antigen remains intact, filtered in a phosphate buffered medium, up to a pH value of 7.1-7.3, through molecular filters passing molecules of up to 100,000 Daltons, the infectiosity being subsequently de-activated by means of formaldehyde, in proportion of 1:2000 by volume, for 96 hours.

REFERENCES:
patent: 3636191 (1972-01-01), Blumberg et al.
patent: 3886270 (1975-05-01), Ackermann
patent: 4017360 (1977-04-01), Bertland et al.
patent: 4118479 (1978-10-01), Prince et al.
patent: 4138287 (1979-02-01), Andersson et al.

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