Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2001-05-03
2003-01-07
Tate, Christopher R. (Department: 1651)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
C424S457000
Reexamination Certificate
active
06503541
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a method for preparation of plant extract powder and oral compositions containing plant extract powder prepared by the same.
2. Description of the Related Arts
To keep teeth healthy and normal is directly related to the maintenance of body's health as well as that of mouth. After having been grown to a certain age, teeth are not be reconstructed nor regenerated and they are exposed to various agents or unclean oral environments which could cause serious dental diseases.
It is generally known that tooth decay and periodontal diseases, which occupy most of oral diseases, are caused by plaque which is generated by oral microbe colony at the teeth's surface. When saliva forms a sticky thin film covering the teeth's surface, the microbes can form colony there. That is to say, tooth decay is caused by corrosion of enamel which occurs when Hydroxyapatite, a main ingredient of teeth, is dissolved by organic acid produced when anaerobic bacteria in plaque metabolize the saccharides. And periodontal diseases are caused by the accompanying accumulation of plaque which overwhelms the host's protection ability. Therefore, to alleviate the periodontal diseases, the activity of causative bacteria of periodontal diseases has to be suppressed and hematocele of gum having inflammation has to be improved and the gum inflammation has to be alleviated.
To prevent tooth decay and periodontal diseases, it has been used fluoride compounds to prevent the corrosion of enamel and antibiotics such as penicillin, erythromycin, tetracycline or antibacterial agents such as chlorhexidine to die out tooth decaying bacteria. But the excess use of fluorine causes the hardening of cartilage and stomachache and the use of bactericides or antibacterial agents cause various side-effects in the mouth.
Therefore, instead of using artificial antibiotics and bactericides, it has been proposed to use medicinal plant extracts which have an effect on causative bacteria of tooth decay and periodontal diseases. Representative examples include Sanguinaria extract(U.S. Pat. No. 4,689,216), Myrrh, Rhatany, Sage, Chamomile and Echinaecia extract(S. de Rysky; Journal of Clinical Dentistry Vol. I. Supplement A. A22-24, 1988), Sage and Rosemary extract (Japanese Patent Publication Sho 58-134,013), or Hop extract(Japanese Patent Publication Sho 62-138,420). But, these various plant extracts. are not stable in the formulation products so that the phase separation of composition is easily occurred.
Therefore, several attempts have been made to stabilize the active principles in the oral compositions. For example, the use of gel capsule to stabilize the oil-soluble ingredient is disclosed in the Japanese Patent Publication Hei 9-110663 as a method for stabilizing the effective ingredients in the oral composition. This gel capsule was prepared through dipping or absorbing the oil-soluble ingredient in inorganic or organic powder carrier and coating it with water-soluble high molecular substance's gel film. But there still exists the problem of instability of composition because the water-soluble coating could be melted when it is injected into the liquid phase oral compositions such as toothpaste during production process or storage.
SUMMARY OF THE INVENTION
The present invention provides a method for preparation of plant extract powder, which comprises the steps of
(a) loading a plant extract having activities of prevention of and treatment for periodontal diseases or tooth decay into a porous powder carrier;
(b) coating said carrier's surface with a water-insoluble coating agent.
The present invention further provides oral compositions containing plant extract powder prepared by the above described method which have an excellent periodontal diseases preventing effect and tooth decay preventing effect.
The present invention will be described in detail below.
DETAILED DESCRIPTION OF THE INVENTION
According to the present invention, the method for preparation of the plant extract powder is characterized in that which comprises the steps of (a) loading a plant extract having activities of prevention of and treatment for periodontal diseases or tooth decay into a porous powder carrier; (b) coating said carrier's surface with a water-insoluble coating agent.
Also, the oral composition of the present invention is characterized in that which contains the plant extract powder prepared by this invention in an amount of 0.05~5.0% by weight.
The method for preparation of the plant extract powder will be described in detail hereinafter.
The step (a) is to load a plant extract having activities of prevention of and treatment for periodontal diseases or tooth decay into a porous powder carrier. Plants which are used in the present invention in the form of extract to treat oral diseases may be selected from one or more of pine, licorice, cassia seed, cinnamon, nothosmyrnium root, sophora, lonicera flower, platycodon, green tea, dayflower, Korean angelica root, liriope rhizome, moutan, Arabian myrrh, seseleos radix, Angelicae Dahuricae Radix, Lagerstroemia indica, morus bark, ginger, sanguinaria, asarum, cimicifuga, Chinese galls, Grapefruit seed, lycium root, cnidium, Alpinia katsumadai Hayata, gardenia, Lythrum salicaria L., dandelion, propolis, flavonoid, nepta herb, Reynoutria japonica Houtt., scutellaria, machilia, black adzuki bean, camomile, ratanhia or Sage oil.
The extraction can be carried out by the general extraction methods such as alcohol digestion, steam distillation, supercritical fluid extraction method by adding cosolvent and the like.
In case of Pine extract, it is used as a form of mixture solution with salt, of which effectiveness of prevention and treatment for periodontal diseases such as gingivitis, alveolar pyorrhea due to astriction to the gum is known, and the mixing ratio of pine extract and salt is 1:0.1~10 by weight.
While there exist various problems in the use of chemical components, which are generally used in oral composition as effective ingredients at present, because diffused chemical components in the mouth could eliminate or dilute the product of bacteria such as enzymes, toxins and antigens as well as bring the direct destruction of component materials of dental plaque so that there coexist various problems such as manufacturing concentration, dose and etc., we could expect the antibiotic, anti-inflammatory and analgesic action of above described plant ext contain essential oils, triterpens, flavonoids, iridoids, alkaloids and etc.
The carrier of the present invention for loading the plant extract may be porous materials(“carrier 1”) having particle size of 5~600 &mgr;m, preferably 100~400 &mgr;m; or porous materials(“carrier 2”) having a primary particle size of 1~100 nm are used.
For the carrier 1, any kind of powder, which has appropriate suction force, chemical stability and physical stability, could be commonly used in the skilled of the art. The examples of powder of the present invention are calcium monohydrogen phosphate, calcium pyrophosphate, calcium carbonate, silicon dioxide, aluminum hydroxide, and insoluble sodium metaphosphate. Also, inorganic abrasives such as aluminum silicate, zirconium silicate, zeolite, aluminum magnesium silicate, diatomite or zirconium oxide and the like can be used as well. Also, the abrasives of high molecular substances, which have been employed in tooth pastes, are useful as carrier for plant extracts because they never release the calcium ion so that fluoride compound, which is the component of an efficacy of a medicine, never lose activation by being disused. The example of high molecular substances as carrier may include, but not limited to, polyethylene, polyvinylchloride, polyester, polystyrene, polypropylene, polyamide, polycarbonate, phenol resins, urea resins, polymethyhnetacrylate resins or melamine resins. While, among abrasives of high molecular substances, polyethylene and polyvinylchloride are more preferable.
For the carrier 2, colloi
Lee Byung Ryeul
Lee Key Hyun
Moon Hyun Soo
Pacific Corporation
Patten Patricia
Tate Christopher R.
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