Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – N-c doai
Patent
1999-02-18
2000-09-26
Geist, Gary
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
N-c doai
564 74, 564 75, A01N 4710
Patent
active
061243493
ABSTRACT:
The present invention provides methods for producing pharmaceutical-grade particulate dithiocarbamates from secondary amines by vigorously contacting at least one secondary amine and a pharmaceutically acceptable diluent that is a solvent for the carbon disulfide, but not for the secondary amine in an inert gas atmosphere, cooling the mixture so as to precipitate the dithiocarbamate therefrom, and separating the precipitated dithiocarbamate from the cooled mixture. The preferred solvent contains absolute ethanol. In alternative embodiments, the invention further provides methods for purifying a dithiocarbamate to obtain a pharmaceutical-grade dithiocarbamate particulate from a dithiocarbamate feed and methods for producing a sterile pharmaceutical-grade dithiocarbamate from a dithiocarbamate feed.
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patent: 5847004 (1998-12-01), Lai
Lee et al., "Sugar-Linked Dithiocarbamates as Modulators of Metabolic and Genotoxic Properties of N-Nitroso Compounds," J. Med. Chem., 37:3154-3162 (1994).
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Lai Ching-San
Liaw Wei-Cheng
Vassilev Vassil P.
Geist Gary
Learn June M.
Medinox Inc.
Oh Taylor V.
Reiter Stephen E.
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