Method for preparation of orally administrated insulin...

Details Method for preparation of orally administrated insulin... Method for preparation of orally administrated insulin...

2006-03-28

2006-03-28

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S003100, C514S938000

Reexamination Certificate

active

07018980

ABSTRACT:
The invention relates to the method for preparation of orally administrated insulin oil formulation comprising: dissolving an amount of insulin in an acidic aqueous buffer(A); adding A to liquid surfactant, the HLB value of which is between 10 and 20, with agitation to form a homogeneous solution(B); adding B to an oil, the HLB value of which is between 0 and 10, with agitation to form oil formulation. This invention has a simple process with low cost. After orally administrated, the formulation prepared with the process of the invention can resist the gastrointestinal degradation by digestive enzymes, and is easily absorbed for hypoglycemic effect.

REFERENCES:
patent: 5824638 (1998-10-01), Burnside et al.
patent: 6258377 (2001-07-01), New et al.
patent: 6368619 (2002-04-01), New et al.
patent: 2003/0166508 (2003-09-01), Zhang
patent: WO 94/08605 (1994-04-01), None

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