Method for preparation of low-phenylalanine plastein

Details Method for preparation of low-phenylalanine plastein Method for preparation of low-phenylalanine plastein

1976-01-16

1977-04-05

Shapiro, Lionel M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260121, 195 29, C07G 700, C12D 1306

Patent

active

040161471

ABSTRACT:
Method for the preparation of a low-phenylalanine plastein comprising hydrolyzing stepwise a certain albumin or globulin protein with an endopeptidase having an affinity for the aromatic acid components, and an exopeptidase, subjecting the hydrolyzate thus-obtained to gel-filtration to divide it into two fractions, one being constituted with aromatic amino acids and the other being constituted with oligopeptides almost free from the aromatic amino acids, and then subjecting the latter fraction to usual plastein synthesis. Tyrosine and/or tryptophan may be added to the substrate at the plastein synthesis in order to incorporate them into the plastein molecules. The resultant plasteins may be purified through ultra-filtration in order to remove the remaining free amino acids and low-molecular peptides.

REFERENCES:
patent: 3803327 (1974-04-01), Fujimaki et al.
Yamashita et al., Agricultural and Biological Chemistry, vol. 38, No. 6, pp. 1269-1271, (1974).

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