Method for preparation of LNA phosphoramidites

Details Method for preparation of LNA phosphoramidites Method for preparation of LNA phosphoramidites

2006-12-26

2006-12-26

Jiang, Shaojia Anna (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S025340, C536S022100

Reexamination Certificate

active

07153954

ABSTRACT:
The present invention relates to large scale preparation of LNA phosphoramidites using a 2-cyanoethyl-N,N,N′,N′-tetra-substituted phosphoramidite and a nucleophilic activator, e.g. 2-cyanoethyl-N,N,N′,N′-tetraisopropylphosphoramidite and 4,5-dicyanoimidazole. The method is faster and more cost efficient that previously known methods.

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Abstract of Poster presented at 4th Winter Conference on Medicinal and Bioorganic Chemistry, Jan. 28 -Feb. 2, 2001.

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